心碎綜合癥與癌癥、大腦對壓力的反應有關

心碎綜合癥與癌癥、大腦對壓力的反應有關

“Broken heart” syndrome, a disease that causes the heart to temporarily weaken, has been linked to the brain’s reaction to stress, a 2019 study has found.

2019年的一項研究發(fā)現，導致心臟暫時變弱的“心碎”綜合癥與大腦對壓力的反應有關。

In an article published in the European Heart Journal in March, Swiss researchers said they found a connection between the way the brain communicates with the heart and broken heart syndrome, also called takotsubo syndrome (TTS).

瑞士研究人員在3月份發(fā)表于《歐洲心臟雜志》(European Heart Journal)的一篇文章中說，他們發(fā)現大腦與心臟溝通的方式與心碎綜合癥(也稱takotsubo綜合征)之間存在聯系。

Caused by intense emotional events, TTS is a rare, temporary condition that weakens the left ventricle and disrupts its normal pumping function.

由強烈的情緒事件引起的TTS是一種罕見的暫時性疾病，它會削弱左心室并破壞其正常的泵血功能。

For their research, Swiss neuroscientists and cardiologists conducted MRI brain scans on 15 TTS patients — on average, about a year after their diagnosis — and compared them to scans of 39 healthy people.

在他們的研究中，瑞士的神經科學家和心臟病學家對15名TTS患者進行了MRI腦部掃描——平均大約是在他們確診后一年——并將他們與39名健康人的腦部掃描進行了比較。

They specifically looked at four brain regions that control emotions, motivation, learning and memory and share information with each other. Two of the regions they analyzed, the amygdala and cingulate gyrus, help control the autonomic nervous system and heart function.

他們專門研究了大腦中控制情緒、動機、學習和記憶以及相互分享信息的四個區(qū)域。他們分析的兩個區(qū)域，杏仁核和扣帶回，幫助控制自主神經系統(tǒng)和心臟功能。

In their analysis of the scans, researchers were able to correlate the function of those regions with TTS.

在對掃描結果的分析中，研究人員能夠將這些區(qū)域的功能與TTS聯系起來。

“We found that TTS patients had decreased communication between brain regions associated with emotional processing and the autonomic nervous system, which controls the unconscious workings of the body, compared to the healthy people,” Christian Templin, research author and professor of cardiology at University Hospital Zurich said in a statement.

研究作者、蘇黎世大學醫(yī)院心臟病學教授克里斯蒂安•坦普林在一份聲明中說:“我們發(fā)現，與健康人相比，接受TTS治療的患者與情緒處理相關的大腦區(qū)域和控制身體潛意識活動的自主神經系統(tǒng)之間的交流減少。”

“For the first time, we have identified a correlation between alterations to the functional activity of specific brain regions and TTS, which strongly supports the idea that the brain is involved in the underlying mechanism of TTS. Emotional and physical stress are strongly associated with TTS and it has been hypothesized that the overstimulation of the autonomic nervous system may lead to TTS events,” Templin added.

“我們首次發(fā)現了大腦特定區(qū)域功能活動的改變與TTS之間的相關性，這有力地支持了大腦參與了TTS潛在機制的觀點。”情緒和身體上的壓力與TTS密切相關，有人推測，自主神經系統(tǒng)的過度刺激可能導致TTS事件。”Templin補充道。

However, researchers were unable to determine if the decrease in communication between the brain and the heart was the cause of TTS or vice versa because they didn’t have MRI scans of the TTS patients’ brains at the time they developed the condition.

然而，研究人員無法確定是大腦和心臟之間的交流減少導致了TTS，還是相反，因為他們沒有對TTS患者發(fā)病時的大腦進行MRI掃描。

“Our results suggest that additional studies should be conducted to determine whether this is a causal relationship,” Dr. Jelena Ghadri, a senior research associate at the University Hospital Zurich and co-author of the study said.

“我們的研究結果表明，應該進行更多的研究，以確定這是否是一種因果關系。”蘇黎世大學醫(yī)院(University Hospital Zurich)的高級研究員、該研究的合著者耶萊娜·加德里(Jelena Ghadri)博士說。

“We hope this study offers new starting points for studying TTS in terms of understanding that it much more than ‘broken heart’ syndrome and clearly involves interactions between the brain and the heart, which are still not fully understood,” Ghadri continued.

Ghadri繼續(xù)說:“我們希望這項研究為TTS的研究提供了新的起點，它不僅僅是‘心碎’綜合癥，而且顯然涉及到大腦和心臟之間的相互作用，這一點我們還沒有完全了解。”