Unit 85
Shortages of flu vaccine are nothing new in America, but this year’s is a whopper. Until last week, it appeared that 100 million Americans would have access to flu shots this fall. Then British authorities, concerned about quality-control problems at a production plant in Liverpool, barred all further shipments by the Chiron Corp. Overnight, the U.S. vaccine supply dwindled by nearly half—and federal health officials found themselves making an unusual plea. Instead of beseeching us all to get vaccinated, they’re now urging most healthy people between the ages of 2 and 64 not to. “This re-emphasizes the fragility of our vaccine supply,” says Dr. Martin Myers of the National Network for Immunization Information, “and the lack of redundancy in our system.”
Why is such a basic health service so easily knocked out? Mainly because private companies have had little incentive to pursue it. To create a single dose of flu vaccine, a manufacturer has to grow live virus in a 2-week-old fertilized chicken egg, then crack the egg, harvest the virus and extract the proteins used to provoke an immune response. Profit margins are narrow, demand is fickle and, because each year’s flu virus is different, any leftover vaccine goes to waste. As a result, the United States now has only two major suppliers (Chiron and Aventis Pasteur)—and when one of them runs into trouble, there isn’t much the other can do about it. “A vaccine maker can’t just call up and order 40 million more fertilized eggs,” says Manon Cox, of Connecticut-based Protein Sciences Corp. “There’s a whole industry that’s scheduled to produce a certain number of eggs at a certain time.”
Sleeker technologies are now in the works, and experts are hoping that this year’s fiasco will speed the pace of innovation. The main challenge is to shift production from eggs into cell cultures—a medium already used to make most other vaccines. Flu vaccines are harder than most to produce this way, but several biotech companies are now pursuing this strategy, and one culture-based product(Solvay Pharmaceuticals’ Invivac)has been cleared for marketing in Europe.
For America, the immediate challenge is to make the most of a limited supply. The government estimates that 95 million people still qualify for shots under the voluntary restrictions announced last week. That’s nearly twice the number of doses that clinics will have on hand, but only 60 million Americans seek out shots in a normal year. In fact, many experts are hoping the shortage will serve as an awareness campaign—encouraging the people who really need a flu shot to get one.
注(1):本文選自Newsweek;
注(2):本文習(xí)題命題模仿對(duì)象:第1~4題分別模仿1997年真題Text 3第1~4題,第5題模仿1997年真題Text 4第4題。
1. Shortages of flue vaccine show that ______.
A) America relies too much on foreign suppliers
B) the demand of flue vaccines is high this year
C) quality problem is a serious problem in flu vaccine production
D) the supply of flu vaccines is rather weak and America has no back-up measures to make it up
2. The word “cleared” (Line 5, Paragraph 3) might mean ______.
A) permitted
B) removed
C) proved
D) produced
3. Private companies have little interest in producing flu vaccines because of ______.
A) complicated process, high cost, low profit and high risk
B) shortages of fertilized chicken eggs
C) difficulty in growing live virus
D) fast changing of flu virus
4. From the last paragraph we can infer that ______.
A) the government hopes to solve the problem by way of volunteer restrictions
B) more than 47 million Americans who are qualified to get flu vaccine shots cannot get them this year
C) America needs not to worry about a limited supply of flu vaccines this year
D) normally only a small percentage of American population gets flu vaccine shots each year
5. According to the passage, which of the following is TRUE?
A) All Americans are persuaded not to get vaccinated this year.
B) The big problem in innovating flu vaccine’s producing technique is how to grow virus in a new way.
C) More flu vaccines cannot be produced in a short time because private companies refuse to produce more.
D) Flu vaccines are easier than most vaccines to produce through cell cultures.
篇章剖析
本篇文章探討了美國(guó)流感疫苗短缺的原因以及今后的解決辦法。第一段,作者介紹了美國(guó)流感疫苗短缺問(wèn)題以及其直接原因;第二段,作者剖析了其背后的經(jīng)濟(jì)原因;第三段,作者介紹了解決短缺問(wèn)題的辦法之一——革新疫苗生產(chǎn)技術(shù),將其從雞蛋培育轉(zhuǎn)移到細(xì)胞培養(yǎng);第四段,作者探討了美國(guó)的當(dāng)務(wù)之急:如何利用好有限的疫苗。出路就是號(hào)召公民發(fā)揚(yáng)風(fēng)格,將注射疫苗的機(jī)會(huì)讓給敏感群體。
詞匯注釋
whopper /?(h)w?p?/ n. 彌天大謊
bar /bɑ?(r)/ v. 禁止
dwindle /?dw?ndl/ v. 縮小
beseech /b??si?t?/ v. 懇求
vaccinate /?v?ks?ne?t/ v. 接種疫苗
fragility /fr??d??l?ti/ n. 脆弱
the National Network for Immunization Information (美國(guó))全國(guó)防疫信息網(wǎng)
redundancy /r??d?nd?nsi/ n. 備份
knock out 擊倒
incentive /?n?sent?v/ n. 動(dòng)機(jī)
fertilized chicken egg已受精雞蛋
crack /kr?k/ v. (使)破裂
harvest /?hɑ?v?st/ v. 收獲
extract /?k?str?kt/ v. 提取
immune response 免疫反應(yīng)
profit margin 利潤(rùn)率
fickle /?f?kl/ adj. 變化無(wú)常的
sleek /sli?k/ adj. 圓滑的;打磨過(guò)的
fiasco /f???sk??/ n. 慘敗
innovation /??n???ve???n/ n. 改革,創(chuàng)新
culture /?k?lt??/ n. 細(xì)菌培養(yǎng)
biotech /ba????tek/ n. 生物技術(shù)
culture-based adj . 基于細(xì)菌培養(yǎng)技術(shù)的
clear /kl??/ v. 批準(zhǔn),準(zhǔn)許
an awareness campaign一場(chǎng)公民道德意識(shí)活動(dòng)
難句突破
“This re-emphasizes the fragility of our vaccine supply,” says Dr. Martin Myers of the National Network for Immunization Information, “and the lack of redundancy in our system.”
主體句式:Dr. Marin Myers says “This re-emphasizes the fragility... and the lack...”
結(jié)構(gòu)分析:該句的難點(diǎn)在于如何理解本句直接引語(yǔ)中兩個(gè)關(guān)鍵詞re-emphasize和redundancy的情感內(nèi)涵。re-emphasize通常表示“再次強(qiáng)調(diào)”,但根據(jù)其賓語(yǔ)中的關(guān)鍵名詞“fragility(脆弱)”和“l(fā)ack(缺乏)”兩個(gè)詞的語(yǔ)義內(nèi)涵判斷,re-emphasize在本句中應(yīng)該表示“凸顯出(問(wèn)題)”。redundancy通常表示“冗余,不必要的重復(fù)”,但在本句中表示“為了避免出現(xiàn)問(wèn)題而采取的應(yīng)急方案”。由此可見(jiàn),根據(jù)具體語(yǔ)境,才能正確理解詞匯的意思。
句子譯文:“這再次凸顯出我們疫苗供應(yīng)的脆弱性,”全國(guó)免疫信息網(wǎng)的馬丁·邁爾斯醫(yī)生說(shuō),“此外,我們也沒(méi)有必要的補(bǔ)救機(jī)制?!?
題目分析
1. D 推理題。第一段最后一句話指出了疫苗短缺所暴露出來(lái)的問(wèn)題?!癟his re-emphasizes the fragility of our vaccine supply,” says Dr. Martin Myers of the National Network for Immunization Information, “and the lack of redundancy in our system.”“這再次凸顯出我們疫苗供應(yīng)的脆弱性,”全國(guó)免疫信息網(wǎng)的馬丁·邁爾斯醫(yī)生說(shuō),“此外,我們也沒(méi)有必要的補(bǔ)救機(jī)制?!边@與選項(xiàng)D的說(shuō)法一致。
2. A 語(yǔ)義題。在第三段最后一句“one culture-based product(Solvay Pharmaceuticals’ Invivac)has been cleared for marketing in Europe ”里出現(xiàn)了cleared一詞。根據(jù)下文中“marketing”和藥品上市前應(yīng)該得到批準(zhǔn)的常識(shí),可以判斷出,該詞在本句中的意思是“得到官方的批準(zhǔn)”。
3. A 細(xì)節(jié)題。第二段第二句“Mainly because private companies have had little incentive to pursue it.”意思是說(shuō)私企生產(chǎn)流感疫苗的積極性不高。接下來(lái)作者介紹了制作疫苗的復(fù)雜工序,由此可以推斷出流感疫苗生產(chǎn)工藝復(fù)雜、成本高。第二段第4~5行“Profit margins are narrow, demand is fickle and, because each year’s flu virus is different, any leftover vaccine goes to waste. ”又明確指出了私企不愿意生產(chǎn)流感疫苗的其他原因:利潤(rùn)率低、需求不穩(wěn)定,此外由于流感病毒每年都不同,因此生產(chǎn)數(shù)量不能過(guò)大。由此也可推斷出生產(chǎn)的風(fēng)險(xiǎn)性大,如果生產(chǎn)多了就會(huì)損失很大。
4. B 推理題。由第四段第二句“The government estimates that 95 million people still qualify for shots under the voluntary restrictions announced last week. ”中可以知道有9500萬(wàn)人有資格注射疫苗。根據(jù)第四段第三句“That’s nearly twice the number of doses that clinics will have on hand, but only 60 million Americans seek out shots in a normal year.”和前一句可以推斷出美國(guó)現(xiàn)有大約4700萬(wàn)份流感疫苗庫(kù)存,由此可推斷出美國(guó)至少還有4700多萬(wàn)有資格注射疫苗的人無(wú)法得到注射。
5. B 細(xì)節(jié)題。從第一段倒數(shù)第二句“Instead of beseeching us all to get vaccinated, they’re now urging most healthy people between the ages of 2 and 64 not to.”可以判斷出美國(guó)只呼吁2~64歲的健康人不接種流感疫苗,而不是所有的美國(guó)人,因此答案A是錯(cuò)誤的。從第二段最后一句可以看出疫苗生產(chǎn)廠家無(wú)法臨時(shí)增加疫苗生產(chǎn)量不是由于他們不愿意,而是由于受精雞蛋的生產(chǎn)已經(jīng)預(yù)先計(jì)劃好,無(wú)法提供更多的受精雞蛋,由此可見(jiàn)答案C是錯(cuò)誤的。從第三段第三句“Flu vaccines are harder than most to produce this way”可以判斷出答案D是錯(cuò)誤的,因?yàn)榱鞲幸呙绫葎e的疫苗更難用細(xì)菌培育的方式生產(chǎn)。而由第三段第二句“The main challenge is to shift production from eggs into cell cultures—a medium already used to make most other vaccines. ”以及上一句可見(jiàn),改造疫苗生產(chǎn)工藝的關(guān)鍵在于革新病毒培育技術(shù),因此答案B是正確的。
參考譯文
流感疫苗短缺在美國(guó)不足為奇,但今年的短缺傳聞卻是一個(gè)彌天大謊。到上周為止,好像還有1億美國(guó)人能在今年秋季接種流感疫苗。緊接著,英國(guó)當(dāng)局因?yàn)閾?dān)心一家位于利物浦的生產(chǎn)廠的質(zhì)量控制問(wèn)題而禁止所有Chiron Corp公司的產(chǎn)品供應(yīng)。一夜之間,美國(guó)的疫苗供應(yīng)量減少了近一半——而聯(lián)邦衛(wèi)生官員也發(fā)現(xiàn)他們正在提出一項(xiàng)不同尋常的請(qǐng)求:不是請(qǐng)求我們?nèi)プ⑸湟呙?,而是敦促那些年齡在2~64歲之間的絕大多數(shù)健康人不去注射疫苗?!斑@再次凸顯出我們疫苗供應(yīng)的脆弱性,”全國(guó)免疫信息網(wǎng)的馬丁·邁爾斯醫(yī)生說(shuō),“此外,我們也沒(méi)有必要的補(bǔ)救機(jī)制?!?
為什么這種基本的保健服務(wù)會(huì)如此不堪一擊呢?主要原因是私人公司生產(chǎn)積極性不高。生產(chǎn)每一份流感疫苗,生產(chǎn)商都要在一枚受精兩星期的雞蛋中培育活病毒,然后打破雞蛋,提取病毒和用來(lái)激發(fā)免疫反應(yīng)的蛋白質(zhì)。利潤(rùn)率低,需求不穩(wěn)定,此外由于每年的流感病毒不同,剩余的疫苗只能報(bào)廢。因此美國(guó)目前只有兩家大的供應(yīng)商(Chiron Corp和Aventis Pasteur)——當(dāng)其中一家公司遇到麻煩時(shí),另一家公司也無(wú)能為力。“疫苗生產(chǎn)商根本不可能打個(gè)電話多要4000萬(wàn)個(gè)受精雞蛋,”在康涅狄格一家蛋白質(zhì)科學(xué)公司工作的馬農(nóng)·考克斯說(shuō),“整個(gè)雞蛋生產(chǎn)都是按計(jì)劃進(jìn)行的。什么時(shí)間生產(chǎn)多少雞蛋都是已經(jīng)預(yù)先計(jì)劃好的?!?
目前的生產(chǎn)已經(jīng)采用更好的技術(shù)。專家們希望今年的教訓(xùn)能夠加快技術(shù)革新的步伐。最大的挑戰(zhàn)是如何將疫苗生產(chǎn)從雞蛋培育轉(zhuǎn)向細(xì)胞培育——該技術(shù)已經(jīng)廣泛應(yīng)用于其他大部分疫苗的生產(chǎn)。用細(xì)胞培育技術(shù)生產(chǎn)流感疫苗比生產(chǎn)其他大部分疫苗難度更大。盡管如此,幾家生物技術(shù)公司正在進(jìn)行這方面的嘗試。索馬爾Invivac醫(yī)藥公司研制的一種基于細(xì)菌培育技術(shù)的產(chǎn)品已經(jīng)獲準(zhǔn)在歐洲銷售。
對(duì)美國(guó)來(lái)說(shuō),當(dāng)務(wù)之急是要利用好有限的流感疫苗。政府預(yù)計(jì),盡管上周發(fā)布了自愿限制公告,仍有9500萬(wàn)人有資格注射疫苗。這個(gè)數(shù)字幾乎是醫(yī)院臨床流感疫苗庫(kù)存量的兩倍。但正常情況下,每年僅有6000萬(wàn)美國(guó)人接種流感疫苗。事實(shí)上,許多專家希望這次疫苗短缺問(wèn)題能成為一次提高公民道德意識(shí)的活動(dòng)——鼓勵(lì)那些確實(shí)需要注射疫苗的人們?nèi)プ⑸洹?
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