研究表明，特應(yīng)性濕疹與各種原因死亡風(fēng)險(xiǎn)的增加有關(guān)

研究表明，特應(yīng)性濕疹與各種原因死亡風(fēng)險(xiǎn)的增加有關(guān)

People with atopic eczema may have an increased chance of death from all causes – particularly infectious diseases – suggests a new study published in the Journal of Allergy and Clinical Immunology. With atopic eczema impacting 10-20% of children and up to 10% of adults worldwide, the results give important insight into how allergy-related conditions may have drastic impacts on overall health.

發(fā)表在《過敏與臨床免疫學(xué)雜志》上的一項(xiàng)新研究表明，患有特應(yīng)性濕疹的人死于各種原因的幾率可能會(huì)增加，尤其是傳染性疾病。特應(yīng)性濕疹影響了全球10-20%的兒童和高達(dá)10%的成年人，研究結(jié)果為了解與過敏相關(guān)的條件如何可能對(duì)整體健康產(chǎn)生劇烈影響提供了重要的見解。

"Recent evidence has led to a paradigm shift in how atopic eczema is perceived, from focusing on skin symptoms and associated allergic diseases, to understanding that the disease may be associated with a range of important medical outcomes. Recently, we found atopic eczema to be associated with an increased risk of myocardial infarction, ischemic stroke, angina and heart failure.” said Sinéad Langan, Professor of Clinical Epidemiology at LSHTM, in a statement.

“最近的證據(jù)導(dǎo)致了對(duì)特應(yīng)性濕疹的認(rèn)知范式的轉(zhuǎn)變，從關(guān)注皮膚癥狀和相關(guān)的過敏性疾病，到理解該疾病可能與一系列重要的醫(yī)學(xué)結(jié)果相關(guān)。最近，我們發(fā)現(xiàn)特應(yīng)性濕疹與心肌梗死、缺血性中風(fēng)、心絞痛和心力衰竭的風(fēng)險(xiǎn)增加有關(guān)。倫敦醫(yī)學(xué)院臨床流行病學(xué)教授Sinéad Langan在一份聲明中說。

"However, few studies have assessed if atopic eczema increases the risk of death, a research question we aimed to address in this study."

“然而，很少有研究評(píng)估特應(yīng)性濕疹是否會(huì)增加死亡風(fēng)險(xiǎn)，這是我們?cè)诒狙芯恐兄荚诮鉀Q的研究問題。”

Jack Dunhill

The study covered over 3 million records of patients that died in the UK from 1998 to 2016, looking for differences between those with atopic eczema and those without. The researchers, from the London School of Hygiene & Tropical Medicine, also aimed to determine whether the severity of eczema changes the risks of all-cause mortality.

該研究涵蓋了1998年至2016年英國死亡的300多萬名患者的記錄，尋找患有特應(yīng)性濕疹和非特應(yīng)性濕疹患者之間的差異。來自倫敦衛(wèi)生與熱帶醫(yī)學(xué)院的研究人員還試圖確定濕疹的嚴(yán)重程度是否會(huì)改變?nèi)蛩劳龅娘L(fēng)險(xiǎn)。

The results demonstrated a weak – but significant – correlation between people with atopic eczema and death from all causes, with an associated 4% risk increase. Diseases that were used as part of all-cause mortality included 15 different distinct causes including respiratory, circulatory and digestive diseases.

結(jié)果表明，特應(yīng)性濕疹患者與各種原因?qū)е碌乃劳鲋g存在微弱但顯著的相關(guān)性，相關(guān)風(fēng)險(xiǎn)增加4%。作為全死因死亡率一部分的疾病包括15種不同的原因，包括呼吸系統(tǒng)、循環(huán)系統(tǒng)和消化系統(tǒng)疾病。

However, the more interesting results came from associations with increased eczema severity and all-cause mortality. Patients with severe manifestations of atopic eczema had a 62% higher risk of dying than those without, with the largest increases seen in death by infections. The reason why is not yet understood, but the researchers express a strong need to understand the underlying mechanisms behind the increase in death rate.

然而，更有趣的結(jié)果來自于濕疹嚴(yán)重程度和全因死亡率的增加。有嚴(yán)重特應(yīng)性濕疹表現(xiàn)的患者的死亡風(fēng)險(xiǎn)比無特應(yīng)性濕疹表現(xiàn)的患者高62%，其中死于感染的人數(shù)增加最多。原因尚不清楚，但研究人員表示強(qiáng)烈需要了解死亡率上升背后的潛在機(jī)制。

This study represents the largest look into the relationship between atopic eczema, all-cause mortality and cause-specific mortality. The findings are in line with previous studies that identified an increased risk of various serious conditions and eczema, suggesting there is a definite link between the two. However, the authors recognize the limitations of the study methodology, in which selection bias – picking subjects related to the study that may not be representative of the population – may skew the data, but steps were taken throughout to limit this as much as possible. Studies such as this serve as a starting point for future lines of inquiry.

本研究對(duì)特應(yīng)性濕疹、全因死亡率和因特異性死亡率之間的關(guān)系進(jìn)行了最大的研究。這一發(fā)現(xiàn)與之前的研究一致，這些研究發(fā)現(xiàn)患各種嚴(yán)重疾病和濕疹的風(fēng)險(xiǎn)增加，這表明兩者之間存在著明確的聯(lián)系。然而，作者認(rèn)識(shí)到研究方法的局限性，在選擇偏倚中——選擇與研究相關(guān)的對(duì)象，可能不代表人群——可能扭曲數(shù)據(jù)，但采取了步驟，以盡可能限制這種情況。這樣的研究可以作為未來研究的起點(diǎn)。

"Although the absolute risk of death from severe eczema is low, our findings suggest that those with severe or more active forms of the disease do face a higher risk of dying from associated health issues. We hope that this new information will help inform further research to better understand this pattern and the underlying mechanisms of these associations, and subsequently inform and improve treatment processes for those with severe eczema." Said Professor Langan.

“雖然死于嚴(yán)重濕疹的絕對(duì)風(fēng)險(xiǎn)很低，但我們的研究結(jié)果表明，那些患有嚴(yán)重或更活躍形式的濕疹的人確實(shí)面臨著更高的死于相關(guān)健康問題的風(fēng)險(xiǎn)。”我們希望這一新的信息將有助于進(jìn)一步研究，更好地理解這種模式和這些關(guān)聯(lián)的潛在機(jī)制，并隨后為嚴(yán)重濕疹患者提供信息和改善治療過程。”蘭甘教授說。